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Phenylvalerophenone (CAS 1009-14-9).also known as 1-phenyl-1-pentanone,is an organic chemical reagent, an organic synthesis intermediate and apharmaceutical intermediate that can be used in laboratory research and development processes and in chemical and pharmaceutical synthesis.(For high purity valerophenone, please feel free to contact kairunute.)
How is valerophenone prepared?
Phenylvalerophenone can be prepared from benzene and n-pentyl chloride by the Foucault reaction or from methyl benzoate by the Grignardreaction.
Method 1: Add 156 g of benzene.900 mL of dichloromethane and 146.5 g of anhydrous aluminium trichloride to a 2 L three-necked flask, lower thetemperature to 0-5C and then slowly add 120.5 g of n-pentyl chloride dropwise to the flask, keeping the internal temperature of the flask at 0-10Cduring the dropwise addition. After the dropwise addition, the temperature was adjusted to 40C and the reaction was allowed to proceed for 2hours with stirring. Under cooling in an ice bath, 500 mL of IN hydrochloric acid solution was added slowly dropwise and partitioned after the drop wise addition. The aqueous phase was then extracted with 400 mL of DCM. The organic phases were combined and then concentrated anddistilled under reduced pressure to give 142 g of phenylpentanone in 87%yield.
Method 2:6.3 mL (0.05 mol) of methyl benzoate and 0.05 g of cuprous iodide were dissolved in anhydrous tetrahydrofuran and 0.05 mol ( ethersolution made with 1.2 g of magnesium metal and the corresponding amount of n-butyl bromide)of alkyl Grignard's reagent was added dropwise, the Grignard's reagent was titrated for about half an hour and then reacted for about three hours to give 7.8 g of the final target product, valerophenone, in 96%yield.
Specification for the use of valerophenone.
When operating valerophenone, the operator must be specially trained and the operating procedure must be strictly observed during the operation.
The workplace must have local ventilation or be fully ventilated, avoid contact with eyes and skin during operation, avoid inhalation of vapours and keep away from fire and heat sources. Avoid smoking in the workplace, use explosion-proof ventilation systems and equipment, avoid contact withoxidisers and other substances, and carry the product lightly to avoid dissolving the box.It is important to wash your hands thoroughly afteroperation and to avoid eating in the workplace, which should also have the appropriate items and quantities of fire-fighting equipment, as well asemergency equipment.
